Combating pancreatic cancer chemoresistance by triggering multiple cell death pathways

Pancreatic cancer is the fourth most common cause of cancer-associated death in western countries, where incidence and number deaths are increasing every year. Intrinsic or acquired resistance tumor cells to chemotherapy agents major reason for failure traditional treatment. Several factors implicated this impressive resistance; however, these, it important highlight extensive cellular heterogeneity these tumors. This linked a wide range sensitivity that different clones same display chemotherapeutic agents. Accordingly, recent findings field have discovered new therapeutic targets order develop combinatory treatments, as well induce several cell pathways reduce therapy-threshold likelihood future resistance. research has focused on targeting mitochondria, an organelle with key roles regulating signaling pathways, such apoptosis, necroptosis, autophagy, ferroptosis, parthanatos. These — identifying compounds, alone combination, can target pancreatic ductal adenocarcinoma could be treatments.